Tocris/MG 101/3358/5/5 MG-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/MG 101/3358/5/5 MG

Tocris/MG 101/3358/5/5 MG

商品编号： 3358/5

品牌： Tocris Bioscience

市场价： ¥2100.00

美元价： 1260.00

产地：美国(厂家直采)

公司：

产品分类：蛋白酶类

公司分类： protease

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Calpaininhibitor;activatesp53-dependentapoptosis

AlternativeNames:Calpaininhibitor-1

ChemicalName:N-Acetyl-L-leucine-L-leucine-L-norleucinal

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Calpaininhibitor(IC₅₀=0.09μM)thatactivatesp53-dependentapoptosisintumorcelllines.Increasesactivatedp53,p21andcaspaselevelsandpromotescellcyclearrestthroughinhibitionofcyclinDdegradationinvitro.Alsoattenuatesischemia/reperfusioninjuryincardiomyocytes,hepatocytesandrenaltubularcellsthroughdownregulationofiNOSandCOX-2expression.

TechnicalData

M.Wt	383.53
Formula	C₂₀H₃₇N₃O₄
Storage	Storeat-20°C
CASNumber	110044-82-1
PubChemID	443118
InChIKey	FMYKJLXRRQTBOR-BZSNNMDCSA-N
Smiles	CCCC[C@H](NC([C@@H](N[C@@]([C@H](CC(C)C)NC(C)=O)=O)CC(C)C)=O)C=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	19.18	50
	ethanol	9.59	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight383.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.61mL	13.04mL	26.07mL
5mM	0.52mL	2.61mL	5.21mL
10mM	0.26mL	1.3mL	2.61mL
50mM	0.05mL	0.26mL	0.52mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

PreparingStockSolutions

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