Biological Activity
Potent and selective HDAC2/3 inhibitor (IC50 values are 16 and 30 nM, respectively). Exhibits >250-fold selectivity for HDAC2/3 over other HDAC isoforms. Promotes apoptosis of leukemia cell lines in vitro. Also attenuates IL-6 production in rheumatoid arthritis PBMCs in vitro.
Technical Data
| M. Wt | 383.44 |
| Formula | C24H21N3O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1415340-63-4 |
| PubChem ID | 56965342 |
| InChI Key | GTLTXEIKQVWSRF-UHFFFAOYSA-N |
| Smiles | C=C1CN(CC2=CC=C(C(NC3=C(N)C=CC=C3)=O)C=C2)C(C4=CC=CC=C41)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.34 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 383.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.04 mL | 26.08 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.22 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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References
References are publications that support the products' biological activity.
Gillespie et al (2012) Histone deacetylases are dysregulated in rheumatoid arthritis and a novel histone deacetylase 3-selective inhibitor reduces interleukin-6 production by peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthrit.Rheumat. 64 418 PMID: 21952924
Boissinot et al (2012) Induction of differentiation and apoptosis in leukaemic cell lines by the novel benzamide family histone deacetylase 2 and 3 inhibitor MI-192. Leuk.Res. 36 1304 PMID: 22818799
Keywords: MI 192, supplier, MI192, potent, selective, HDAC2, HDAC3, histones, deacetylases, Histone, Deacetylases, Histone, Deacetylases, Tocris Bioscience
