Biological Activity
MALT1 inhibitor (IC50 = 5.84 μM). Binds directly to MALT1 and irreversibly suppresses protease function. Decreases NF-κB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) tumor xenografts in mice and primary human ABC-DLBCLs ex vivo.
Technical Data
| M. Wt | 455.72 |
| Formula | C19H17Cl3N4O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1047953-91-2 |
| PubChem ID | 45942672 |
| InChI Key | TWJGQZBSEMDPQP-UHFFFAOYSA-N |
| Smiles | O=C(CCl)NC(C=C3)=CC=C3N1C(C2=CC(Cl)=C(Cl)C=C2)=NC(OCCOC)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.57 | 100 | |
| ethanol | 9.11 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 455.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.97 mL | 21.94 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.39 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Fontan et al (2012) MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo. Cancer Cell 22 812 PMID: 23238016
Keywords: MI 2 (MALT1 inhibitor), supplier, MI2, MALT, 1, inhibitors, inhibits, NF-KB, NFKB, NF, Kappa, B, NFκB, lymphoma, ABC-DLBCL, Other, Proteases, Other, Proteases, Tocris Bioscience
