Biological Activity
Potent and selective CB1 receptor antagonist (Ki = 27.2 pM, IC50 = 118.9 pM for rat CB1 receptors). Exhibits potency in obesity and hyperlipidemia models; inhibits food intake and increases in body weight in diet-induced obese rats and mice.
Licensing Information
Sold under licence.
Compound Libraries
MJ 15 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 471.77 |
| Formula | C23H17Cl3N4O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 944154-76-1 |
| PubChem ID | 59377482 |
| InChI Key | PJEIKJFNEFJFLA-UHFFFAOYSA-N |
| Smiles | ClC1=CC(Cl)=CC=C1N2C(C3=CC=C(Cl)C=C3)=C(C)C(C(NCC4=CC=CN=C4)=O)=N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.18 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 471.77. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.6 mL | 21.2 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Chen et al (2010) Novel, selective antagonist of the cannabinoid CB1 receptor, MJ15, with prominent anti-obesity effect in rodent models. Eur.J.Pharmacol. 637 178 PMID: 20380831
Keywords: MJ 15, supplier, MJ15, CB1, receptors, antagonist, cannabinoid, receptors, 1, antagonists, obesity, dyslipidemia, dyslipidaemia, CB1, Receptors, CB1, Receptors, Tocris Bioscience
