Tocris/MK 0343/4415/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/MK 0343/4415/50/50 mg

Tocris/MK 0343/4415/50/50 mg

商品编号： 4415/50

品牌： Tocris Bioscience

市场价： ¥18500.00

美元价： 11100.00

产地：美国(厂家直采)

公司：

产品分类：信号通路

公司分类： Signal_pathway

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Subtype-selectiveGABA_AreceptorpartialagoNIST

ChemicalName:7-Cyclobutyl-3-(2,6-difluorophenyl)-6-[(1-methyl-1H-1,2,4-triazol-5-yl)methoxy]-1,2,4-triazo[4,3-b]pyridazine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Subtype-selectiveGABA_Apartialagonist(K_ivaluesare0.21,0.22,0.23and0.40forα3,α1,α5andα2respectively);occupiesthebenzodiazepinesiteofGABA_Areceptors.Displaysgreateragonistefficacyatα3comparedtoα1.Exhibitsanxiolyticandnon-sedatingpropertiesinrodentmodels.Brainpenetrant.

CompoundLibraries

MK0343isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	397.38
Formula	C₁₉H₁₇F₂N₇O
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	233275-76-8
PubChemID	22609888
InChIKey	GOIFCXRIFSYPFG-UHFFFAOYSA-N
Smiles	FC(C=CC=C3F)=C3C1=NN=C2N1N=C(OCC5=NC=NN5C)C(C4CCC4)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	39.74	100
	ethanol	19.87	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight397.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.52mL	12.58mL	25.16mL
5mM	0.5mL	2.52mL	5.03mL
10mM	0.25mL	1.26mL	2.52mL
50mM	0.05mL	0.25mL	0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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BiologicalActivity

CompoundLibraries

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets