Biological Activity
TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.
Technical Data
| M. Wt | 336.47 |
| Formula | C16H20N2O2S2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1062271-24-2 |
| PubChem ID | 18191179 |
| InChI Key | IRGYSXZCDAWOOC-UHFFFAOYSA-N |
| Smiles | CC3=CC=C(S3)S(NC1=CC=CC=C1N2CCCCC2)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.65 | 100 | |
| ethanol | 6.73 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 336.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.86 mL | 29.72 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.94 mL |
| 10 mM | 0.3 mL | 1.49 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Chen et al (2014) A small molecule restores function to TRPML1 mutant isoforms responsible for mucolipidosis type IV. Nat.Commun. 5 4681 PMID: 25119295
Keywords: MK6-83, supplier, TRPML, transient, receptor, potential, channels, activators, activates, mucolipidosis, MLIV, TRPML, TRPML, Tocris Bioscience
