Biological Activity
Potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo.
Compound Libraries
ML 10302 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 349.25 |
| Formula | C15H21ClN2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 186826-17-5 |
| PubChem ID | 56972230 |
| InChI Key | HBLRTSYSGOFQCK-UHFFFAOYSA-N |
| Smiles | ClC1=CC(C(OCCN2CCCCC2)=O)=C(OC)C=C1N.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.46 | 50 | |
| ethanol | 6.99 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 349.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.86 mL | 14.32 mL | 28.63 mL |
| 5 mM | 0.57 mL | 2.86 mL | 5.73 mL |
| 10 mM | 0.29 mL | 1.43 mL | 2.86 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.57 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Yang et al (1997) New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J.Med.Chem. 40 608 PMID: 9046352
Cachard-Chastel et al (2007) 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br.J.Pharmacol. 150 883 PMID: 17325649
Ponti et al (2001) Intestinal motor stimulation by the 5-HT4 receptor agonist ML10302: differential involvement of tachykininergic pathways in the canine small bowel and colon. Neurogastroenterol.Mot. 13 543 PMID:
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