Biological Activity
Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation.
Compound Libraries
ML 161 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 361.23 |
| Formula | C17H17BrN2O2 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 423735-93-7 |
| PubChem ID | 1048267 |
| InChI Key | DFOVLSMXPWPCFH-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC(NC(CCC)=O)=CC=C2)C1=CC=CC=C1Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.12 | 100 | |
| ethanol | 36.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 361.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.84 mL | 27.68 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.54 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Dockendorff et al (2012) Discovery of 1,3-diaminobenzenes as selective inhibitors of platelet activation at the PAR1 receptor. ACS Med.Chem.Lett. 3 232 PMID: 22408714
Keywords: ML 161, supplier, ML161, inhibitors, inhibits, protease-activated, proteinase-activated, receptors, par1, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
