Biological Activity
Selective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.
Technical Data
| M. Wt | 488.58 |
| Formula | C27H32N6O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1355244-02-8 |
| PubChem ID | 44665680 |
| InChI Key | PMTIWRPLQBVEMR-UHFFFAOYSA-N |
| Smiles | O=C(CN4C(C3=CC=CN3C5=C4N=CC=C5C)=O)NCCCN(CC2)CCN2C1=CC=C(OC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.77 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 488.58. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.05 mL | 10.23 mL | 20.47 mL |
| 5 mM | 0.41 mL | 2.05 mL | 4.09 mL |
| 10 mM | 0.2 mL | 1.02 mL | 2.05 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.41 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Frankowski et al (2012) Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 3 221 PMID: 22737280
Hedrick et al (2011) Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro PMID: 22091479
Keywords: ML 190, supplier, ML190, selective, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP, Kappa, Opioid, Receptors, Kappa, Opioid, Receptors, Tocris Bioscience
