Biological Activity
Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6 μM in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22 μM.
Technical Data
| M. Wt | 226.32 |
| Formula | C15H18N2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 5465-86-1 |
| PubChem ID | 230710 |
| InChI Key | USYRQXDHKXGTCK-UHFFFAOYSA-N |
| Smiles | CC2=CC(N3CCCCC3)=NC1=CC=CC=C12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 5.66 | 25mM with gentle warming | |
| DMSO | 22.63 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 226.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 5 mM | 0.88 mL | 4.42 mL | 8.84 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.42 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Miller et al (2011) Novel chemical inhibitor of TRPC4 channels. Probe Reports from the Molecular Libraries Program PMID: 22049577
Miller et al (2011) Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/5 ion channels. J.Biol.Chem. 286 33436 PMID: 21795696
Keywords: ML 204, supplier, ML204, TRPC4, blockers, transient, receptor, potential, channels, canonical, TRPC, TRPC, TRPC, Tocris Bioscience
