Biological Activity
Selective KV7.2 (KCNQ2) and KV7.4 (KCNQ4) channel opener (EC50 values are 230 and 510 nM for KV7.2 and KV7.4 respectively). Displays > 80-fold selectivity against KV7.1, KV7.3 and KV7.5 in a thallium-based fluorescence assay.
Compound Libraries
ML 213 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 257.37 |
| Formula | C17H23NO |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 489402-47-3 |
| PubChem ID | 3111211 |
| InChI Key | SIQGKPGBLYKQBB-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(C)C=C(C)C=C3C)C1CC2CCC1C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12.87 | 50 | |
| ethanol | 12.87 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 257.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.89 mL | 19.43 mL | 38.85 mL |
| 5 mM | 0.78 mL | 3.89 mL | 7.77 mL |
| 10 mM | 0.39 mL | 1.94 mL | 3.89 mL |
| 50 mM | 0.08 mL | 0.39 mL | 0.78 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Yu et al (2011) Discovery, synthesis, and structure activity relationship of a series of N-aryl-bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a novel KCNQ2 and KCNQ4 potassium channel opener. ACS Chem.Neurosci. 2 572 PMID: 22125664
Keywords: ML 213, supplier, ML213, KCNQ2, KCNQ4, channels, openers, kv7.2, kv7.4, potassium, K+, voltage, gated, potassium, Kv, Voltage-Gated, Potassium, Channels, Voltage-Gated, Potassium, Channels, Tocris Bioscience
