BiologicalActivity
HIFpathwayactivator(EC50valuesare1.23and1.4μMforHREgenereporterassayandHIF-1αnucleartranslocationassayrespectively);actsviachelationofiron,independentlyofPHD.Alsoexhibits>80%inhibitionofthehumanA3receptor,dopaminetransporter,μreceptor,hERGand5-HT2Breceptor,andratsodiumchannelsite2,ataconcentrationof10μM.
CompoundLibraries
ML228isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 415.49 |
| Formula | C27H21N5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1357171-62-0 |
| PubChemID | 46742353 |
| InChIKey | QNRODODTMXCRKU-UHFFFAOYSA-N |
| Smiles | C1(C2=NC(NCC4=CC=C(C5=CC=CC=C5)C=C4)=C(C3=CC=CC=C3)N=N2)=NC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.55 | 100 | |
| ethanol | 8.31 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight415.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.41mL | 12.03mL | 24.07mL |
| 5mM | 0.48mL | 2.41mL | 4.81mL |
| 10mM | 0.24mL | 1.2mL | 2.41mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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