Biological Activity
Non-peptide apelin receptor agonist (EC50 = 3.7 μM); exhibits >21-fold selectivity over the closely related angiotensin 1 receptor (EC50 = >79 μM).
Technical Data
| M. Wt | 359.44 |
| Formula | C19H21NO4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 60138111 |
| InChI Key | RSMZOLWJZGIWOV-CZIZESTLSA-N |
| Smiles | CC(/C(C=C1C2CCCCC2)=N/OS(C3=CC=CC=C3)(=O)=O)=CC1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.97 | 50 | |
| ethanol | 3.59 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 359.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.91 mL | 27.82 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.56 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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References
References are publications that support the products' biological activity.
Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. Trends Pharmacol Sci. 36 560 PMID: 26143239
Khan et al (2011) Functional agonists of the apelin (APJ) receptor. Probe Reports from the NIH Molecular Libraries Program PMID: 22834038
Keywords: ML 233, supplier, ML233, Potent, non, peptide, agonists, APJ, Receptors, Apelin, adipokines, Apelin, Receptors, Apelin, Receptors, Tocris Bioscience
