Biological Activity
Inhibitor of the serine/threonine kinase STK33 (IC50 = 14 nM). Exhibits >700-fold selectivity for STK33 over the structurally related protein kinase A (PKA); also exhibits 550-fold selectivity over Aurora kinase B.
Compound Libraries
ML 281 is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox II. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 389.47 |
| Formula | C22H19N3O2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1404437-62-2 |
| PubChem ID | 53377448 |
| InChI Key | HWOYIOLMBQSTQS-UHFFFAOYSA-N |
| Smiles | CC(C)C1=CC(C2=NC(C=CC=C3)=C3NC2=O)=C(NC(C4=CC=CS4)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.95 | 100 | |
| ethanol | 3.89 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 389.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.57 mL | 12.84 mL | 25.68 mL |
| 5 mM | 0.51 mL | 2.57 mL | 5.14 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.57 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Weiwer et al (2012) A potent and selective quinoxaline-based STK33 inhibitor does not show synthetic lethality in KRAS-dependent cells. ACS Med.Chem.Lett. 3 1034 PMID: 23256033
Keywords: ML 281, supplier, ML281, STK33, kinases, inhibitors, inhibits, selective, Other, Kinases, Other, Kinases, Tocris Bioscience
