BiologicalActivity
SelectiveKir3.1/3.2(GIRK1/2)channelactivator(IC50valuesare160,887and914nMforGIRK1/2,GIRK1/4andGIRK1/3respectively).ExhibitsnoeffectonGIRK2,GIRK2/3,Kir2.1andKv7.4channels,andhasminimaleffectonapanelofotherionchannels,receptorsandtransporters.PreventsPTZ-inducedepilepticseizuresinmice.Brainpenetrant.
CompoundLibraries
ML297isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 328.32 |
| Formula | C17H14F2N4O |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 1443246-62-5 |
| PubChemID | 56642816 |
| InChIKey | IEKSMUSSYJUQMY-UHFFFAOYSA-N |
| Smiles | O=C(NC2=CC(C)=NN2C3=CC=CC=C3)NC1=CC(F)=C(F)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 32.83 | 100 | |
| ethanol | 16.42 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight328.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.05mL | 15.23mL | 30.46mL |
| 5mM | 0.61mL | 3.05mL | 6.09mL |
| 10mM | 0.3mL | 1.52mL | 3.05mL |
| 50mM | 0.06mL | 0.3mL | 0.61mL |
MolarityCalculator
ReconstitutionCalculator
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ProductDatasheets
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