Biological Activity
Potent and selective hCXCR6 antagonist (IC50 = 140 nM); 100-fold less active at the murine CXCR6 receptor (IC50 = 18 μM). Exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors (IC50 >79 μM).
Technical Data
| M. Wt | 502 |
| Formula | C26H32ClN3O5 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 60202254 |
| InChI Key | SSPYAPRDKNCABY-UHFFFAOYSA-N |
| Smiles | O=C(NC1=C(Cl)C=CC=C1)CN2[C@H]3CCC[C@@H]2C[C@](NC(C4=CC(OC)=C(OC)C(OC)=C4)=O)([H])C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.2 | 100 | |
| ethanol | 10.04 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 502. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.99 mL | 9.96 mL | 19.92 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.98 mL |
| 10 mM | 0.2 mL | 1 mL | 1.99 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
Molarity Calculator
Reconstitution Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Hershberger et al (2012) Probing the CXCR6/CXCL16 Axis: targeting prevention of prostate cancer metastasis. Probe Reports from the NIH Molecular Libraries Program PMID: 24049849
Keywords: ML 339, supplier, ML339, Potent, human, CXCR6, antagonists, antagonism, metastasis, Chemokine, CXC, Receptors, Chemokine, CXC, Receptors, Tocris Bioscience
