Tocris/ML 347/4945/10/10 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/ML 347/4945/10/10 mg

Tocris/ML 347/4945/10/10 mg

商品编号： 4945/10

品牌： Tocris Bioscience

市场价： ¥3980.00

美元价： 2388.00

产地：美国(厂家直采)

公司：

产品分类：氨基酸

公司分类： aminophenol

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:PotentandselectiveALK1andALK2inhibitor

AlternativeNames:LDN193719,1lWY,VU0469381

ChemicalName:5-[6-(4-Methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveALK2andALK1inhibitor(IC₅₀valuesare32and46nM,respectively);displays>200foldselectivityoverALK3andALK6and>400foldselectivityoverVEGF2.ExhibitsnoactivityatALK4,ALK5orinapanelofrelatedkinases.InhibitsBMP4signalinginafunctionalassay(IC₅₀=152nM).

CompoundLibraries

ML347isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	352.39
Formula	C₂₂H₁₆N₄O
Storage	Storeat+4°C
Purity	≥98%(HPLC)
CASNumber	1062368-49-3
PubChemID	44577753
InChIKey	FVRYPYDPKSZGNS-UHFFFAOYSA-N
Smiles	COC(C=C3)=CC=C3C(C=N2)=CN1C2=C(C4=CC=CC5=C4C=CC=N5)C=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	7.05	20

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight352.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.84mL	14.19mL	28.38mL
5mM	0.57mL	2.84mL	5.68mL
10mM	0.28mL	1.42mL	2.84mL
50mM	0.06mL	0.28mL	0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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PreparingStockSolutions

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