Biological Activity
Selective PAR4 antagonist (IC50 = 140 nM). Exhibits 70-fold selectivity for PAR4 over PAR1.
Technical Data
| M. Wt | 282.29 |
| Formula | C16H14N2O3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 89159-60-4 |
| PubChem ID | 752812 |
| InChI Key | GNJUKVGDCUKDLF-UHFFFAOYSA-N |
| Smiles | CN2C1=CC=C([N+]([O-])=O)C=C1C(C3=CC=CC=C3)=C2CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.23 | 100 | |
| ethanol | 2.82 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 282.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.71 mL | 35.42 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Wen et al (2014) Substituted indoles as selective protease activated receptor 4 (PAR4) antagonists: Discovery and SAR of ML354. Bioorg.Med.Chem.Lett. 24 4708 PMID: 25176330
Keywords: ML 354, supplier, ML354, SID161004646, VU0099704, selective, protease, activated, receptors, PAR4, antagonists, Protease-Activated, Receptors, Protease-Activated, Receptors, Tocris Bioscience
