Biological Activity
Selective MrgX1 (SNSR4) positive allosteric modulator (EC50 = 190 nM). Exhibits selectivity for MrgX1 over MrgX2, MrgC11 and a panel of 68 other GPCRs, ion channels and transporters. Enhances BAM (8-22) potency at MrgX1 by 7-fold.
Technical Data
| M. Wt | 360.43 |
| Formula | C18H20N2O4S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1646499-97-9 |
| PubChem ID | 71598556 |
| InChI Key | RCSLEKLNDJJJLF-UHFFFAOYSA-N |
| Smiles | O=C(NC1=C(OCC)C=CC=C1)C2=C(NS(C3CC3)(=O)=O)C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.04 | 100 | |
| ethanol | 7.21 | 20mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 360.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.87 mL | 27.74 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wen et al (2015) Discovery and characterization of 2-(cyclopropanesulfonamido)-N-(2-ethoxyphenyl)benzamide, ML382: a potent and selective positive allosteric modulator of MrgX1. ChemMedChem 10 57 PMID: 25209672
Keywords: ML 382, supplier, ML382, VU0485891, MrgX1,, SNSR4, sensory, neuron-specific, receptors, positive, allosteric, modulators, selective, Sensory, Neuron-Specific, Receptors, Sensory, Neuron-Specific, Receptors, Tocris Bioscience
