Biological Activity
Selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).
Compound Libraries
ML 9 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Kinase Inhibitor Toolbox I. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 361.29 |
| Formula | C15H17ClN2O2S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 105637-50-1 |
| PubChem ID | 108047 |
| InChI Key | ZNRYCIVTNLZOGI-UHFFFAOYSA-N |
| Smiles | Cl.ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)N1CCCNCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.03 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 361.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.77 mL | 13.84 mL | 27.68 mL |
| 5 mM | 0.55 mL | 2.77 mL | 5.54 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.77 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377 PMID: 1605572
Seto et al (1991) Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 195 267 PMID: 1874276
Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118 PMID: 19187978
Hidaka and Hagiwara (1987) Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162 PMID:
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