Biological Activity
G protein-biased D2 receptor partial agonist (Ki = 1.2 μM). Stimulates D2 receptor G protein-mediated signaling and acts as an antagonist of dopamine-mediated β-arrestin recruitment at D2 receptors.
Technical Data
| M. Wt | 354.83 |
| Formula | C19H19ClN4O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 315698-36-3 |
| PubChem ID | 1093278 |
| InChI Key | OPEJNANYABTIGC-UHFFFAOYSA-N |
| Smiles | OC1=C(C=C(C2=C1N=CC=C2)Cl)CN3CCN(C4=CC=CC=N4)CC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.48 | 100 | |
| ethanol | 3.55 | 10mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 354.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.82 mL | 14.09 mL | 28.18 mL |
| 5 mM | 0.56 mL | 2.82 mL | 5.64 mL |
| 10 mM | 0.28 mL | 1.41 mL | 2.82 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Free et al (2014) Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor. Mol.Pharmacol. 86 96 PMID: 24755247
Keywords: MLS 1547, supplier, MLS1547, dopamine, D2, DA, partial, agonists, agonism, G, protein, biased, signaling, D2, Receptors, D2, Receptors, Tocris Bioscience
