Biological Activity
Specific inhibitor of calmodulin-sensitive cyclic GMP phosphodiesterase (IC50 = 5.2 μM).
Technical Data
| M. Wt | 266.3 |
| Formula | C12H18N4O3 |
| Storage | Store at RT |
| CAS Number | 78033-08-6 |
| PubChem ID | 155806 |
| InChI Key | NBLBCGUCPBXKOV-UHFFFAOYSA-N |
| Smiles | COCC1=NC2=C(N1)N(CC(C)C)C(=O)N(C)C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in ethanol |
Preparing Stock Solutions
The following data is based on the product molecular weight 266.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.76 mL | 18.78 mL | 37.55 mL |
| 5 mM | 0.75 mL | 3.76 mL | 7.51 mL |
| 10 mM | 0.38 mL | 1.88 mL | 3.76 mL |
| 50 mM | 0.08 mL | 0.38 mL | 0.75 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Wells and Mille (1988) Methylxanthine inhibitors of phosphodiesterases. Methods Enzymol. 159 489 PMID: 2457788
Keywords: MMPX, supplier, PDE1, inhibitors, inhibits, calmodulin-sensitive, cyclic, GMP, phosphodiesterases, Phosphodiesterases, Phosphodiesterases, Tocris Bioscience
