Biological Activity
Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC50 = 12.7 μM for thrombin-induced platelet aggregation). Exhibits no effects on Ca2+-dependent enzymes, PKC or arachidonic acid metabolism.
Technical Data
| M. Wt | 193.16 |
| Formula | C9H7NO4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1485-00-3 |
| PubChem ID | 672296 |
| InChI Key | KFLWBZPSJQPRDD-ONEGZZNKSA-N |
| Smiles | O=[N+](/C=C/C1=CC(OCO2)=C2C=C1)[O-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.32 | 100 | |
| ethanol | 0.97 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 193.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.18 mL | 25.89 mL | 51.77 mL |
| 5 mM | 1.04 mL | 5.18 mL | 10.35 mL |
| 10 mM | 0.52 mL | 2.59 mL | 5.18 mL |
| 50 mM | 0.1 mL | 0.52 mL | 1.04 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Wang et al (2006) Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor. Mol.Pharmacol. 70 1380 PMID: 16837624
Wang et al (2007) Synthesis and pharmacological evaluation of novel γ-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem.Pharmacol. 74 601 PMID: 17601492
Keywords: MNS, supplier, Glycoprotein, IIb/IIIa, αIIbβ3, alphaIIbβ3, beta3, inhibits, inhibitors, Src, Syk, Adhesion, Molecules, Kinases, Src, Kinases, Syk, Kinase, Cell, Adhesion, Molecules, Integrins, Src, Kinases, Tocris Bioscience
