Tocris/MP A08/5803/50/50 mg-免疫在线蚂蚁淘旗下平台

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商品详细Tocris/MP A08/5803/50/50 mg

Tocris/MP A08/5803/50/50 mg

商品编号： 5803/50

品牌： Tocris Bioscience

市场价： ¥12580.00

美元价： 7548.00

产地：美国(厂家直采)

公司：

产品分类：其它酶

公司分类： Other_enzymes

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:SelectiveATPcompetitiveSphK1and2inhibitor;cellpermeable

AlternativeNames:NSC122314

ChemicalName:4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveATPcompetitivesphingosinekinase2and1(SphK2/1)inhibitor(K_ivaluesare6.9and27μM,respectively).ExhibitsselectivityforSphK1and2overotherkinases.InhibitscellularS1Pproductionandincreasessphingosineandceramidelevelsinvitro.Alsoinducesmitochondrial-associatedapoptosis.Reducestumorgrowthinahumanlungadenocarcinomaxenograftmousemodel,byinducingapoptosisandsuppressingangiogenesis.Cellpermeable.

TechnicalData

M.Wt	519.64
Formula	C₂₇H₂₅N₃O₄S₂
Storage	Storeat-20°C
CASNumber	219832-49-2
PubChemID	420266
InChIKey	FLDBNMYJUMAXDQ-UHFFFAOYSA-N
Smiles	O=S(NC1=CC=CC=C1/N=C/C2=CC=CC=C2NS(C3=CC=C(C)C=C3)(=O)=O)(C4=CC=C(C)C=C4)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	51.96	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight519.64.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.92mL	9.62mL	19.24mL
5mM	0.38mL	1.92mL	3.85mL
10mM	0.19mL	0.96mL	1.92mL
50mM	0.04mL	0.19mL	0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

TechnicalData

SolubilityData

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