Biological Activity
Melatonin receptor agonist, 20-fold selective for the MT2 (vs MT1) subtype. At human recombinant MT1 and MT2 receptors, displays pKi values of 8.23 and 8.95 respectively.
Compound Libraries
8-M-PDOT is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 233.31 |
| Formula | C14H19NO2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 134865-70-6 |
| PubChem ID | 5170952 |
| InChI Key | RVIGBTUDFAGRTQ-UHFFFAOYSA-N |
| Smiles | CCC(=O)NC1CCC2=C(C1)C(OC)=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 50 mM in ethanol and to 100 mM in DMSO |
Preparing Stock Solutions
The following data is based on the product molecular weight 233.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.29 mL | 21.43 mL | 42.86 mL |
| 5 mM | 0.86 mL | 4.29 mL | 8.57 mL |
| 10 mM | 0.43 mL | 2.14 mL | 4.29 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Browning et al (2000) Pharmacological characterization of human recombinant melatonin mt1 and MT2 receptors. Br.J.Pharmacol. 129 877 PMID: 10696085
Dubocovich et al (1997) Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroceptor. Naunyn Schmiedebergs Arch.Pharmacol. 355 365 PMID: 9089668
Dubocovich et al (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083
Keywords: 8-M-PDOT, supplier, Melatonin, agonists, Receptors, MT, 8MPDOT, Melatonin, (MT), Receptors, Melatonin, (MT), Receptors, Tocris Bioscience
