Biological Activity
Potent and highly selective antagonist for the human adenosine A3 receptor. Ki values are 2.69 nM at hA3, and > 100 μM at rat A1 and rat A2A receptors.
Licensing Information
Sold with the permission of the NIH, US Patent 60/029,855
Technical Data
| M. Wt | 522.56 |
| Formula | C31H26N2O6 |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 192053-05-7 |
| PubChem ID | 4519822 |
| InChI Key | QFLOJAMZLQXHFS-UHFFFAOYSA-N |
| Smiles | CCOC(=O)C1=C(C)NC(C2=CC=CC=C2)=C(C1C#CC1=CC=CC=C1)C(=O)OCC1=CC=C(C=C1)N(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.26 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 522.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.91 mL | 9.57 mL | 19.14 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.83 mL |
| 10 mM | 0.19 mL | 0.96 mL | 1.91 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.38 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Baraldi and Borea (2000) New potent and selective human adenosine A3 receptor antagonists. TiPS 21 456 PMID: 11121831
Li et al (1998) Structure-activity relationships and molecular modeling of 3,5-diacyl-2,4-dialkylpyridine derivatives as selective A3 adenosine receptor antagonists. J.Med.Chem. 41 3186 PMID: 9703464
Keywords: MRS 1334, supplier, Potent, selective, hA3, antagonists, Receptors, adenosines, MRS1334, Adenosine, A3, Receptors, Adenosine, A3, Receptors, Tocris Bioscience
