Biological Activity
Potent and selective adenosine A2B receptor inverse agonist (Ki values are 1.39, 157, 112 and 230 nM for human A2B, A1, A2A and A3 receptors respectively).
Licensing Information
Manufactured and sold under license from Adenosine Therapeutics, LLC
Technical Data
M. Wt | 503.56 |
Formula | C27H29N5O5 |
Storage | Store at +4°C |
Purity | ≥96% (HPLC) |
CAS Number | 264622-53-9 |
PubChem ID | 5139184 |
InChI Key | ZKUCFFYOQOJLGT-UHFFFAOYSA-N |
Smiles | O=C(C(NC(C3=CC=C(OCC(NC4=CC=C(C(C)=O)C=C4)=O)C=C3)=N2)=C2N1CCC)N(CCC)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 2.52 | 5 |
Preparing Stock Solutions
The following data is based on the product molecular weight 503.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.99 mL | 9.93 mL | 19.86 mL |
5 mM | 0.4 mL | 1.99 mL | 3.97 mL |
10 mM | 0.2 mL | 0.99 mL | 1.99 mL |
50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165 PMID: 10737749
Li et al (2007) ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J.Pharmacol.Exp.Ther. 320 637 PMID: 17077318
Kiec-Kononowicz et al (2001) New developments in A1 and A2 adenosine receptor antagonists. Pure Appl.Chem. 73 1411 PMID:
Keywords: MRS 1706, supplier, Potent, selective, A2B, inverse, agonists, Receptors, adenosines, MRS1706, Adenosine, A2B, Receptors, Adenosine, A2B, Receptors, Tocris Bioscience