Biological Activity
Selective adenosine A2B receptor antagonist (Ki values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA2B, rA1, hA1, hA2A, hA3 and rA2A receptors respectively).
Licensing Information
Sold with the permission of the University of Virginia Patent Foundation
Technical Data
| M. Wt | 486.52 |
| Formula | C26H26N6O4 |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 264622-58-4 |
| PubChem ID | 6603931 |
| InChI Key | AJBBEYXFRYFVNM-UHFFFAOYSA-N |
| Smiles | CCCN1C2=C(NC(=N2)C2=CC=C(OCC(=O)NC3=CC=C(C=C3)C#N)C=C2)C(=O)N(CCC)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.43 | 5mM with gentle warming | |
| DMSO | 4.87 | 10mM with sonication |
Preparing Stock Solutions
The following data is based on the product molecular weight 486.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.06 mL | 10.28 mL | 20.55 mL |
| 5 mM | 0.41 mL | 2.06 mL | 4.11 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.41 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Kim et al (2000) Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J.Med.Chem. 43 1165 PMID: 10737749
Ji et al (2001) [3H]MRS 1754, a selective antagonist radioligand for A2B adenosine receptors. Biochem.Pharmacol. 61 657 PMID: 11266650
Nemeth et al (2007) Adenosine receptor activation ameliorates type I diabetes. FASEB J. 21 2380 PMID:
Keywords: MRS 1754, supplier, Selective, A2B, antagonists, Receptors, adenosines, MRS1754, Adenosine, A2B, Receptors, Adenosine, A2B, Receptors, Tocris Bioscience
