Biological Activity
A selective potentiator of ATP-evoked responses at rat P2X1 receptors (EC50 = 5.9 μM).
Technical Data
| M. Wt | 231.14 |
| Formula | C8H10NO5P |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 14141-47-0 |
| PubChem ID | 3960826 |
| InChI Key | KCAJHODRYGNBSX-UHFFFAOYSA-N |
| Smiles | OC1=C(C)N=CC(CO2)=C1COP2(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 1.16 | 5 | |
| 1eq. NaOH | 23.11 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 231.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.33 mL | 21.63 mL | 43.26 mL |
| 5 mM | 0.87 mL | 4.33 mL | 8.65 mL |
| 10 mM | 0.43 mL | 2.16 mL | 4.33 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.87 mL |
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References
References are publications that support the products' biological activity.
Jacobson et al (1998) A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonise activation of P2X1 receptors. J.Med.Chem. 41 2201 PMID: 9632352
Keywords: MRS 2219, supplier, Potentiates, P2X1-mediated, responses, P2X, Receptors, Purinergic, modulators, purinoceptors, MRS2219, P2X, Receptors, P2X, Receptors, Tocris Bioscience
