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商品详细Tocris/MRS 2279/2158/1/1 mg

Tocris/MRS 2279/2158/1/1 mg

商品编号： 2158/1

品牌： Tocris Bioscience

市场价： ¥6780.00

美元价： 4068.00

产地：美国(厂家直采)

公司：

产品分类：受体

公司分类： Receptors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description:Selective,highaffinityP2Y₁antagoNIST

ChemicalName:(1R*,2S*)-4-[2-Chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanoldihydrogenphosphateesterdiammoniumsalt

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selective,highaffinitycompetitiveantagonistoftheP2Y₁receptor(K_i=2.5nM;IC₅₀=51.6nM).FailstoblocknucleotidesignalingatmostotherP2Yreceptors(P2Y₂,P2Y₄,P2Y₆,P2Y₁₁andP2Y₁₂)andpotentlyinhibitsADP-inducedaggregationofhumanbloodplateletsinvitro(pK_B=8.05).

LicensingInformation

SoldunderlicensefromtheNIH,USPatent10/169975

TechnicalData

M.Wt	503.78
Formula	C₁₃H₁₈ClN₅O₈P₂.2NH₃
Storage	Desiccateat-20°C
Purity	≥98%(HPLC)
CASNumber	367909-40-8
PubChemID	90488744
InChIKey	MLPKPDFUVMQAOX-KOVKCLEESA-N
Smiles	ClC4=NC1=C(C(NC)=N4)N=CN1[C@H]2C[C@H](OP(O)(O)=O)[C@@]3(COP(O)(O)=O)[C@@H]2C3.N.N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	water	50.38	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight503.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.98mL	9.92mL	19.85mL
5mM	0.4mL	1.98mL	3.97mL
10mM	0.2mL	0.99mL	1.98mL
50mM	0.04mL	0.2mL	0.4mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

LicensingInformation

TechnicalData

SolubilityData

PreparingStockSolutions

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ProductDatasheets