Biological Activity
Potent P2Y6 agonist (EC50 = 12 nM). Displays 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively.
Technical Data
| M. Wt | 1042.94 |
| Formula | C19H28N5O20P3.3(C2H5)3N |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1228271-30-4 |
| PubChem ID | 90488923 |
| InChI Key | UCQYWKBGVXRIQK-BJFMRLMLSA-N |
| Smiles | O[C@@H]1[C@@H](N2C(NC(C=C2)=O)=O)O[C@@H](COP(OP(OP(OC[C@H]3O[C@@H](N4C(NC(C=C4)=NOC)=O)[C@H](O)[C@@H]3O)([O-])=O)([O-])=O)([O-])=O)[C@@H]1O.CC[NH+](CC)CC.CC[NH+](CC)CC.CC[NH+](CC)CC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in water (supplied pre-dissolved at a concentration of 10mM) |
Preparing Stock Solutions
The following data is based on the product molecular weight 1042.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.96 mL | 4.79 mL | 9.59 mL |
| 5 mM | 0.19 mL | 0.96 mL | 1.92 mL |
| 10 mM | 0.1 mL | 0.48 mL | 0.96 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.19 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Maruoka et al (2010) Pyrimidine ribonucleotides with enhanced selectivity as P2Y6 receptor agonists: novel 4-alkyloxyimino, (S)-methanocarba, and 5'-triphosphate γ-ester modifications. J.Med.Chem. 53 4488 PMID: 20446735
Keywords: MRS 2957 triethylammonium salt, supplier, MRS2957, triethylammonium, salt, potent, selective, purinergics, purines, purinoceptors, p2y6, agonists, Purinergic, P2Y, Receptors, Purinergic, P2Y, Receptors, Tocris Bioscience
