BiologicalActivity
PotentandselectivetypeIPRMTinhibitor(IC50valuesare8,8,30,83and119nMforPRMT6,PRMT8,PRMT1,PRMT4andPRMT3,respectively).ExhibitsnosignificantactivityagainsttypeIIandIIIPRMTs,PKMTs,DNMTs,KDMsandreaderproteins.Reducesglobalarginineasymmetricdimethylationlevelsinvitro.
LicensingInformation
ThisprobeissuppliedinconjunctionwiththeStructuralGenomicsConsortium.Forfurthercharacterizationdetails,pleasevisittheMS023probesummaryontheSGCwebsite.
ExternalPortalInformation
Chemicalprobes.orgisaportalthatoffersindependentguidanceontheselectionand/orapplicationofsmallmoleculesforresearch.TheuseofMS023isreviewedonthechemicalprobeswebsite.
TechnicalData
| M.Wt | 360.32 |
| Formula | C17H25N3O.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| PubChemID | 121513886 |
| InChIKey | HCNXCUFNZWGILO-UHFFFAOYSA-N |
| Smiles | CC(C)OC1=CC=C(C2=CNC=C2CN(CCN)C)C=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.03 | 100 | |
| water | 36.03 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight360.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.78mL | 13.88mL | 27.75mL |
| 5mM | 0.56mL | 2.78mL | 5.55mL |
| 10mM | 0.28mL | 1.39mL | 2.78mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |
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ProductDatasheets
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