Biological Activity
Potent and selective type I PRMT inhibitor (IC50 values are 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Exhibits no significant activity against type II and III PRMTs, PKMTs, DNMTs, KDMs and reader proteins. Reduces global arginine asymmetric dimethylation levels in vitro.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the MS023 probe summary on the SGC website.
External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of MS023 is reviewed on the chemical probes website.
Technical Data
| M. Wt | 360.32 |
| Formula | C17H25N3O.2HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 121513886 |
| InChI Key | HCNXCUFNZWGILO-UHFFFAOYSA-N |
| Smiles | CC(C)OC1=CC=C(C2=CNC=C2CN(CCN)C)C=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 36.03 | 100 | |
| water | 36.03 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 360.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.78 mL | 13.88 mL | 27.75 mL |
| 5 mM | 0.56 mL | 2.78 mL | 5.55 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.56 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Eram et al (2016) A potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases. ACS Chem.Biol. 11 772 PMID: 26598975
Keywords: MS 023 dihydrochloride, supplier, MS023, dihydrochloride, potent, Type-1, selective, PRMT, inhibitors, inhibits, PRMT6, PRMT8, PRMT1, PRMT4, PRMT3, Protein, Arginine, Methyltransferases, Protein, Arginine, Methyltransferases, Tocris Bioscience
