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当前位置: 首页 > 产品中心 > Other_enzymes > Tocris/MSC 2032964A/5641/10/10 mg
商品详细Tocris/MSC 2032964A/5641/10/10 mg
Tocris/MSC 2032964A/5641/10/10 mg
Tocris/MSC 2032964A/5641/10/10 mg
商品编号: 5641/10
品牌: Tocris Bioscience
市场价: ¥3780.00
美元价: 2268.00
产地: 美国(厂家直采)
公司:
产品分类: 其它酶
公司分类: Other_enzymes
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
Description:PotentandselectiveASK1inhibitor;orallybioavailable
ChemicalName:N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveASK1inhibitor(IC50=93nM).SelectiveforASK1overapanelof210kinases.BlocksLPS-inducedASK1andp38phosphorylationinculturedmouseastrocytes.SuppressesneuroinflammationinamouseEAEmodel.Orallybioavailableandbrainpenetrant.

TechnicalData

M.Wt362.31
FormulaC16H13F3N6O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1124381-43-6
PubChemID25214468
InChIKeyXUKGFHHTSUKORV-UHFFFAOYSA-N
SmilesO=C(C1=CC=CN=C1)NC2=NN3C(C=C(C(F)(F)F)C=C3NC4CC4)=N2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO7.2520
ethanol3.6210mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight362.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.76mL13.8mL27.6mL
5mM0.55mL2.76mL5.52mL
10mM0.28mL1.38mL2.76mL
50mM0.06mL0.28mL0.55mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet