Biological Activity
Endogenous melanocortin MC3 receptor agonist (pKi = 7.46) that displays ~ 40-fold selectivity over MC4. Increases the release of extracellular dopamine, which induces grooming and vertical activity (rearing) in rats. Exhibits hypertensive, tachycardic and short-term analgesic activity in vivo.
Technical Data
| M. Wt | 1512.76 |
| Formula | C72H97N21O14S |
| Sequence |
YVMGHFRWDRF (Modifications: Phe-11 = C-terminal amide) |
| Storage | Store at -20°C |
| CAS Number | 72629-65-3 |
| PubChem ID | 57339641 |
| InChI Key | SLEIICTWQFRIFM-SLNSXFHGSA-N |
| Smiles | [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in 20% acetonitrile / water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1512.76. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.66 mL | 3.31 mL | 6.61 mL |
| 5 mM | 0.13 mL | 0.66 mL | 1.32 mL |
| 10 mM | 0.07 mL | 0.33 mL | 0.66 mL |
| 50 mM | 0.01 mL | 0.07 mL | 0.13 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Versteeg et al (1998) Melanocortins and cardiovascular regulation. Eur.J.Pharmacol. 360 1 PMID: 9845266
Lindblom et al (1998) Autoradiographic discrimination of melanocortin receptors indicates that the MC3 subtype dominates in the medial rat brain. Brain Res. 810 161 PMID: 9813305
Jansone et al (2004) Opposite effects of γ1- and γ2-melanocyte stimulating hormone on regulation of the dopaminergic mesolimbic system in rats. Neurosci.Lett. 361 68 PMID: 15135895
Keywords: gamma1-MSH, supplier, Selective, MC3R, receptor, agonists, Receptors, Melanocortin, γ1-MSH, gamma1-MSH, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience
