Biological Activity
Group II/group III metabotropic glutamate receptor antagonist, showing selectivity for group II in electrophysiological studies.
Technical Data
| M. Wt | 233.23 |
| Formula | C10H11N5O2 |
| Storage | Store at RT |
| CAS Number | 169209-66-9 |
| PubChem ID | 1212 |
| InChI Key | OZBFBAYESADVDX-UHFFFAOYSA-N |
| Smiles | CC(N)(C(O)=O)C1=CC=C(C=C1)C1=NN=NN1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 233.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.29 mL | 21.44 mL | 42.88 mL |
| 5 mM | 0.86 mL | 4.29 mL | 8.58 mL |
| 10 mM | 0.43 mL | 2.14 mL | 4.29 mL |
| 50 mM | 0.09 mL | 0.43 mL | 0.86 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
on-line. Please contact Customer Service
References
References are publications that support the products' biological activity.
Bedingfield et al (1996) Novel potent selective phenylglycine antagonists of metabotropic glutamate receptors. Eur.J.Pharmacol. 309 71 PMID: 8864696
Bushell et al (1996) Pharmacological antagonism of the actions of group II and group III mGluR agonists in the lateral perforant path of rat hippocampal slices. Br.J.Pharmacol. 117 1457 PMID: 8730739
Jane et al (1995) New phenylglycine derivatives with potent and selective antagonist activity at presynaptic glutamate receptors in neonatal rat spinal cord. Neuropharmacology 34 851 PMID: 8532166
Keywords: MTPG, supplier, Group, II, group, III, mGlur, antagonists, selective, Receptors, mGlu2, mGlu3, mGluR3, mGluR2, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, II, Receptors, Glutamate, (Metabotropic), Group, II, Receptors, Tocris Bioscience
