BiologicalActivity
SelectiveCCR5antagonist;displayspotentanti-HIV-1activity.PreventstheinteractionofHIV-1gp120andCCR5(IC50=6.4nM),inhibitingHIV-1entry.Exhibitsantinociceptiveeffectsinaratmodelofneuropathicpain.AlsoinhibitsCCL3(MIP-1α)bindingtoCCR5.Orallybioavailable.
LicensingInformation
SoldforresearchpurposesunderagreementfromViiv.
CompoundLibraries
MaravirocisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 513.67 |
| Formula | C29H41F2N5O |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 376348-65-1 |
| PubChemID | 483407 |
| InChIKey | GSNHKUDZZFZSJB-ILVMPNSOSA-N |
| Smiles | O=C(C4CCC(F)(F)CC4)N[C@@H](CCN2C3CCC2CC(N5C(C)=NN=C5C(C)C)C3)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.53 | 75 | |
| ethanol | 51.37 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight513.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.95mL | 9.73mL | 19.47mL |
| 5mM | 0.39mL | 1.95mL | 3.89mL |
| 10mM | 0.19mL | 0.97mL | 1.95mL |
| 50mM | 0.04mL | 0.19mL | 0.39mL |
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ProductDatasheets
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