Biological Activity
Potent and highly selective agonist at A1 adenosine receptors (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant A1, A2A, A2B and A3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC50 value of 13.1 nM.
Compound Libraries
2'-MeCCPA is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 383.83 |
| Formula | C16H22ClN5O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 205171-12-6 |
| PubChem ID | 10475082 |
| InChI Key | MMPAUXMIDJWGFO-ROMFRFKVSA-N |
| Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC3=C2N=C(Cl)N=C3NC4CCCC4)[C@@](C)1O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.6 | 25 |
Preparing Stock Solutions
The following data is based on the product molecular weight 383.83. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.61 mL | 13.03 mL | 26.05 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.21 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.61 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.52 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Franchetti et al (1998) 2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies. J.Med.Chem. 41 1708 PMID: 9572897
Cappellacci et al (2005) Synthesis, biological evaluation, and molecular modeling of ribose-modified adenosine analogues as adenosine receptor agonists. J.Med.Chem. 48 1550 PMID: 15743197
Keywords: 2'-MeCCPA, supplier, selective, potent, A1, receptor, agonists, Receptors, adenosines, 2-MeCCPA, Adenosine, A1, Receptors, Adenosine, A1, Receptors, Tocris Bioscience
