Biological Activity
Non-competitive nicotinic acetylcholine receptor antagonist. Displays antidepressant-like effects in mice.
Technical Data
| M. Wt | 203.75 |
| Formula | C11H21N.HCl |
| Storage | Desiccate at RT |
| CAS Number | 826-39-1 |
| PubChem ID | 13221 |
| InChI Key | PKVZBNCYEICAQP-UHFFFAOYSA-N |
| Smiles | CC1(C)C2CCC(C2)C(NC)1C.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.28 | 75 | |
| water | 20.37 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 203.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.91 mL | 24.54 mL | 49.08 mL |
| 5 mM | 0.98 mL | 4.91 mL | 9.82 mL |
| 10 mM | 0.49 mL | 2.45 mL | 4.91 mL |
| 50 mM | 0.1 mL | 0.49 mL | 0.98 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Ostroumov et al (2007) Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur.Biophys.J. 37 393 PMID: 17938901
Rabenstein et al (2006) The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not β2- or α7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacol. 189 395 PMID:
Keywords: Mecamylamine hydrochloride, supplier, Non-competitive, nicotinic, receptors, antagonists, Acetylcholine, Non-Selective, Subtypes, nAChR, Nicotinic, Receptors, (Non-selective), Nicotinic, Receptors, (Non-selective), Tocris Bioscience
