Biological Activity
High affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.
Technical Data
| M. Wt | 1024.19 |
| Formula | C50H69N15O9 |
| Sequence |
XDHFRWK (Modifications: X = Nle & N-terminal Ac, Asp-2 = beta-Asp, Phe-4 = D-Phe, Lys-7 = epsilon-Lys, Cyclized = Asp-2 - Lys-7, C-terminal amide) |
| Storage | Desiccate at -20°C |
| CAS Number | 121062-08-6 |
| PubChem ID | 92432 |
| InChI Key | JDKLPDJLXHXHNV-MFVUMRCOSA-N |
| Smiles | CCCC[C@H](NC(C)=O)C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](CC2=CC=CC=C2)NC(=O)[C@H](CC2=CNC=N2)NC1=O)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 1 mg/ml in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 1024.19. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.98 mL | 4.88 mL | 9.76 mL |
| 5 mM | 0.2 mL | 0.98 mL | 1.95 mL |
| 10 mM | 0.1 mL | 0.49 mL | 0.98 mL |
| 50 mM | 0.02 mL | 0.1 mL | 0.2 mL |
Molarity Calculator
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Product Datasheets
References
References are publications that support the products' biological activity.
Martin et al (2002) Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 454 71 PMID: 12409007
Ter Laak et al (2003) The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur.J.Pharmacol. 462 179 PMID: 12591111
Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 395 PMID:
Keywords: Melanotan II, supplier, High, affinity, melanocortin, receptor, agonists, MC, Receptors, MelanotanII, MT-II, Melanocortin, Receptors, Melanocortin, Receptors, Tocris Bioscience
