Biological Activity
5-HT2A and 2C receptor antagonist (pA2 values are 9.1 for each receptor) and D2-like dopamine receptor partial agonist (Ki = 8 nM). Displays antiprolactin and antiparkinsonian effects in vivo.
Technical Data
| M. Wt | 398.95 |
| Formula | C18H26N4O2S.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 72786-12-0 |
| PubChem ID | 155746 |
| InChI Key | HANSYUJEPWNHIM-IVMONYBCSA-N |
| Smiles | CN2C1=CC=CC([C@]4([H])[C@@](N(C)C[C@@H](NS(=O)(N(C)C)=O)C4)([H])C3)=C1C3=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.9 | 100 | |
| water | 1.99 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 398.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.53 mL | 25.07 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.01 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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References
References are publications that support the products' biological activity.
Hoyer et al (1994) VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol.Rev. 46 157 PMID: 7938165
Marko (1984) Dopamine agonistic potency of two novel prolactin release-inhibiting ergolines. Eur.J.Pharmacol. 101 263 PMID: 6468500
Markstei (1983) Mesulergine and its 1,20-N,N-bidemethylated metabolite interact directly with D1- and D2-receptors. Eur.J.Pharmacol. 95 101 PMID: 6230246
Keywords: Mesulergine hydrochloride, supplier, 5-HT2A, 5-HT2C, 5-HT, serotonin, antagonists, D2, dopamine, partial, agonists, antiprolactin, antiParkinsonian, CU-32-085, 5-HT2A, Receptors, Non-selective, Dopamine, 5-HT2C, Receptors, 5-HT2A, Receptors, Tocris Bioscience
