Biological Activity
Antagonist at 5-HT1/5-HT2 with activity at 5-HT1D. Has moderate affinity for 5-HT6 and high affinity for 5-HT7.
Compound Libraries
Metergoline is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 403.52 |
| Formula | C25H29N3O2 |
| Storage | Store at RT |
| CAS Number | 17692-51-2 |
| PubChem ID | 28693 |
| InChI Key | WZHJKEUHNJHDLS-QTGUNEKASA-N |
| Smiles | [H][C@](CNC(OCC5=CC=CC=C5)=O)1C[C@@](C2=CC=CC3=C2C(C4)=CN3C)([H])[C@]4([H])N(C1)C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.35 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 403.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.48 mL | 12.39 mL | 24.78 mL |
| 5 mM | 0.5 mL | 2.48 mL | 4.96 mL |
| 10 mM | 0.25 mL | 1.24 mL | 2.48 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Aulakh et al (1992) Effects of various serotonin receptor subtype selective antagonists alone and on m-chlorophenylpiperazine-induced neuroendocrine changes in rats. J.Pharmacol.Exp.Ther. 263 588 PMID: 1432690
Bagdy et al (1992) Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists. Eur.J.Pharmacol. 210 285 PMID: 1535317
Miller et al (1992) Agonist activity of sumatriptan and metergoline at the human 5-HT1Dβ receptor in the action of sumatriptan. Eur.J.Pharmacol. 227 99 PMID: 1330643
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