Biological Activity
Potent 5-HT2 antagonist, also active as 5-HT1 antagonist. Differentiates 5-HT1D sub-types. Also displays affinity for rodent 5-HT5B, 5-HT5A, 5-HT7 and 5-HT6 receptors (pK1 values are 6.6, 7.0, 8.4 and 8.7 respectively).
Compound Libraries
Methiothepin maleate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 472.62 |
| Formula | C20H24N2S2.C4H4O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 19728-88-2 |
| PubChem ID | 5358812 |
| InChI Key | IWDBEHWZGDSFHR-BTJKTKAUSA-N |
| Smiles | [H]OC(=O)C=C/C(=O)O[H].CSC1=CC2=C(SC3=C(CC2N2CCN(C)CC2)C=CC=C3)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.26 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 472.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.12 mL | 10.58 mL | 21.16 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.23 mL |
| 10 mM | 0.21 mL | 1.06 mL | 2.12 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Wilkinson and Middlemiss (1992) Metitepine distinguishes two receptors mediating inhibition of [3H]-5-hydroxytryptamine release in guinea pig hippocampus. Naunyn Schmiedebergs Arch.Pharmacol. 345 696 PMID: 1321958
Hoyer (1989) The peripheral actions of 5-HT. Ed. Fozard. Oxford. PMID:
Keywords: Methiothepin maleate, supplier, moderate, affinity, 5-ht5, high, 5-ht6, 5-HT7, antagonists, 5-HT1, 5-HT2, Serotonin, 5-HT-, 5-Hydroxytryptamine, Receptors, 5-HT, Metitepine, Non-selective, 5-HT, Non-selective, 5-HT, Tocris Bioscience
