Biological Activity
Indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 = 7 μM); disrupts tryptophan catabolism. Enhances the antitumor and antiviral immunoresponses of CD8+ T-cells in vitro. Reduces tumor volume in mice with xenografts overexpressing IDO.
Technical Data
| M. Wt | 218.25 |
| Formula | C12H14N2O2 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 110117-83-4 |
| PubChem ID | 405012 |
| InChI Key | ZADWXFSZEAPBJS-SNVBAGLBSA-N |
| Smiles | CN1C=C(C[C@H](C(O)=O)N)C2=CC=CC=C21 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.09 | 5mM with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 218.25. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.58 mL | 22.91 mL | 45.82 mL |
| 5 mM | 0.92 mL | 4.58 mL | 9.16 mL |
| 10 mM | 0.46 mL | 2.29 mL | 4.58 mL |
| 50 mM | 0.09 mL | 0.46 mL | 0.92 mL |
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References
References are publications that support the products' biological activity.
Nakamura et al (2015) Effects of indoleamine 2,3-dioxygenase inhibitor in non-Hodgkin lymphoma model mice. Int.J.Hematol. 102 327 PMID: 26243621
Rytelewski et al (2014) Suppression of immunodominant antitumor and antiviral CD8+ T cell responses by indoleamine 2,3-dioxygenase. PLoS One 9 e90439 PMID: 24587363
Keywords: 1-Methyl-D-tryptophan, supplier, 1, MT, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, 1MT, IDO, IDO, Tocris Bioscience
