Biological Activity
A potent blocker of glutamate transport; selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).
Technical Data
| M. Wt | 161.16 |
| Formula | C6H11NO4 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 63088-04-0 |
| PubChem ID | 90479741 |
| InChI Key | GZKDJYLZHGMSFM-KSTNSCRMSA-N |
| Smiles | N[C@@]([C@@]([H])(C)CC(O)=O)([H])C(O)=O.[H][C@](CC(O)=O)(C)[C@@](N)([H])C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble to 100 mM in 1eq. NaOH |
Preparing Stock Solutions
The following data is based on the product molecular weight 161.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.21 mL | 31.03 mL | 62.05 mL |
| 5 mM | 1.24 mL | 6.21 mL | 12.41 mL |
| 10 mM | 0.62 mL | 3.1 mL | 6.21 mL |
| 50 mM | 0.12 mL | 0.62 mL | 1.24 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Eliasof et al (2001) Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J.Neurochem. 77 550 PMID: 11299317
Mitrovic et al (1998) Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J.Biol.Chem. 273 14698 PMID: 9614067
Vandenberg et al (1997) Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol.Pharmacol. 51 809 PMID: 9145919
Keywords: (±)-threo-3-Methylglutamic acid, supplier, EAAT2, EAAT4, blockers, Excitatory, Amino, Acid, Transporters, GLT-1, Glutamate, Monoamine, Neurotransmitter, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience
