Biological Activity
Potent, high affinity H4 receptor agonist (Ki = 7 nM) that displays > 100-fold selectivity over other human histamine receptor subtypes.
Technical Data
| M. Wt | 198.09 |
| Formula | C6H11N3.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 36376-47-3 |
| PubChem ID | 215819 |
| InChI Key | BVJIXYJOFWYOBL-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CC1=C(CCN)NC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 246.8 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.05 mL | 25.24 mL | 50.48 mL |
| 5 mM | 1.01 mL | 5.05 mL | 10.1 mL |
| 10 mM | 0.5 mL | 2.52 mL | 5.05 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1.01 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Lim et al (2005) Evaluation of histamine H1-, H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J.Pharmacol.Exp.Ther. 314 1310 PMID: 15947036
Gbahou et al (2006) Compared pharmacology of human histamine H3 and H4 receptors: structure-activity relationships of histamine derivatives. Br.J.Pharmacol 147 74 PMID:
Keywords: 4-Methylhistamine dihydrochloride, supplier, Selective, high, affinity, H4, agonists, Receptors, Histamine, histaminergic, Histamine, H4, Receptors, Histamine, H4, Receptors, Tocris Bioscience
