Biological Activity
Potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Also displays agonist properties at H4 receptors to which it binds with moderate affinity (Ki = 23 nM).
Technical Data
| M. Wt | 198.09 |
| Formula | C6H11N3.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 16503-22-3 |
| PubChem ID | 16078977 |
| InChI Key | AYUQICXJAMPXPF-UHFFFAOYSA-N |
| Smiles | Cl.Cl.CNCCC1=CNC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| phosphate buffered saline | 19.81 | 100 | |
| water | 19.81 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 198.09. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.05 mL | 25.24 mL | 50.48 mL |
| 5 mM | 1.01 mL | 5.05 mL | 10.1 mL |
| 10 mM | 0.5 mL | 2.52 mL | 5.05 mL |
| 50 mM | 0.1 mL | 0.5 mL | 1.01 mL |
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References
References are publications that support the products' biological activity.
Hill et al (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45 PMID: 2164693
Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13 PMID: 1695431
Zweig et al (1992) Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein. J.Neurochem. 59 1661 PMID: 1328529
Keywords: N-Methylhistamine dihydrochloride, supplier, Non-Selective, H3, agonists, Receptors, Histamine, histaminergic, Nalpha-Methylhistamine, dihydrochloride, Histamine, H3, Receptors, Histamine, H3, Receptors, Tocris Bioscience
