Biological Activity
5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM).
Technical Data
| M. Wt | 226.71 |
| Formula | C11H14N2O.HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 845861-49-6 |
| PubChem ID | 11492320 |
| InChI Key | ZNVRHQPXSBWLQP-UHFFFAOYSA-N |
| Smiles | Cl.CC1=C(CCN)C2=CC(O)=CC=C2N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.67 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 226.71. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.41 mL | 22.05 mL | 44.11 mL |
| 5 mM | 0.88 mL | 4.41 mL | 8.82 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the products' biological activity.
Craig et al (1990) 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch.Pharmacol. 342 9 PMID: 2402303
Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Ismaiel et al (1990) 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 33 755 PMID: 2299641
Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683 PMID: 1968974
Keywords: 2-Methyl-5-hydroxytryptamine hydrochloride, supplier, 5-HT3, agonists, potent, 5-HT6, ligand, Serotonin, Receptors, 2-Me-5HT, 2, methyl5HT, 5-HT3, Receptors, 5-HT6, Receptors, 5-HT3, Receptors, Tocris Bioscience
