Biological Activity
Highly selective, potent competitive inhibitor of iNOS.
Technical Data
| M. Wt | 278.36 |
| Formula | C4H14N4O4S3 |
| Storage | Store at RT |
| CAS Number | 867-44-7 |
| PubChem ID | 13347 |
| InChI Key | BZZXQZOBAUXLHZ-UHFFFAOYSA-N |
| Smiles | NC(SC)=[NH2+].NC(SC)=[NH2+].[O-]S([O-])(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solubility | Soluble in water |
Preparing Stock Solutions
The following data is based on the product molecular weight 278.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.59 mL | 17.96 mL | 35.92 mL |
| 5 mM | 0.72 mL | 3.59 mL | 7.18 mL |
| 10 mM | 0.36 mL | 1.8 mL | 3.59 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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References
References are publications that support the products' biological activity.
Iuvone et al (1997) Differential effect of L-NAME and S-methyl-isothiourea on leukocyte emigration in carrageenin-soaked sponge implants in rat. Br.J.Pharmacol. 121 1637 PMID: 9283697
Southan et al (1995) Isothioureas - potent inhibitors of nitric oxide synthases with variable isoform selectivity. Br.J.Pharmacol. 114 510 PMID: 7533622
Keywords: (S)-Methylisothiourea sulfate, supplier, selective, iNOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, SMT, iNOS, iNOS, Tocris Bioscience
