Biological Activity
Potent antagonist for α7-containing neuronal nicotinic receptors (Ki = 1.4 nM). Interacts with α4β2 and α6β2 receptors at concentrations > 40 nM. Attenuates METH-induced neurotoxicity in mouse striatum in vivo.
Compound Libraries
Methyllycaconitine citrate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 874.93 |
| Formula | C37H50N2O10.C6H8O7 |
| Storage | Desiccate at -20°C |
| CAS Number | 112825-05-5 |
| PubChem ID | 90479749 |
| InChI Key | INBLZNJHDLEWPS-IRPACCRLSA-N |
| Smiles | OC(=O)CC(O)(CC(O)=O)C(O)=O.[H][C@@]12C[C@H]3[C@H](OC)[C@]1([H])[C@](O)(C[C@@H]3OC)[C@]1(O)[C@@H](OC)C3[C@@]22[C@H]1N(CC)C[C@]3(COC(=O)C1=CC=CC=C1N1C(=O)C[C@H](C)C1=O)CC[C@@H]2OC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 87.49 | 100 | |
| water | 87.49 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 874.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.14 mL | 5.71 mL | 11.43 mL |
| 5 mM | 0.23 mL | 1.14 mL | 2.29 mL |
| 10 mM | 0.11 mL | 0.57 mL | 1.14 mL |
| 50 mM | 0.02 mL | 0.11 mL | 0.23 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Dobelis et al (1999) Effects of delphinium alkaloids on neuromuscular transmission. J.Pharmacol.Exp.Ther. 291 538 PMID: 10525069
Escubedo et al (2005) Methyllycaconitine prevents methamphetamine-induced effects in mouse striatum: involvement of α7 nicotinic receptors. J.Pharmacol.Exp.Ther. 315 658 PMID: 16076935
Ward et al (1990) Methyllycaconitine: a selective probe for neuronal a-bungarotoxin binding sites. FEBS Lett. 270 45 PMID: 2226787
Keywords: Methyllycaconitine citrate, supplier, α7, alpha7, a7, neuronal, nicotinic, receptors, antagonists, Nicotinic, Acetylcholine, nAChR, MLA, Nicotinic, (a7), Receptors, Nicotinic, (a7), Receptors, Tocris Bioscience
